Three people have died after a plane that took off from George Airport crashed into mountainous terrain near Mossel Bay on Thursday, Western Cape emergency services confirmed.
Western Cape health's Emergency Medical Services (EMS) confirmed the crash, having dispatched three vehicles and skymed air support around noon.
"The incident took place at 11:30 and sadly, three patients, two males and a female were fatally injured," said EMS spokesperson Deanna Bessick.
"The wreckage was found at 14:05. Our sincere condolences to the family of the deceased as circumstances around the crash is being investigated."
Earlier on Thursday, the South African Civil Aviation Authority (SACAA) said it lost contact with its flight inspection unit aircraft that took off from George Airport in the Southern Cape.
"The crew, two males and one female, took off at 10:40 (local time) from the George Airport on a flight calibration mission of navigational aids of the same airport," SACAA said in a statement.
"The air traffic control tower could not make contact with the aircraft ten minutes after take-off. The Air Traffic and Navigation Services immediately activated search and rescue."
SACAA said it was in contact with the search and rescue team and would provide further information later in the day.
*This story has been updated.